What We Know About Fibromyalgia So Far

In most cases of Fibromyalgia, the causes are not known, however, common factors which may contribute have included physical injuries, viral infections, severe sleep disturbance, chronic fatigue and emotional trauma.

Abnormalities which have been found in individuals suffering from fibromyalgia include the following:
Sleep
• decreased activity in opioid receptors in parts of the brain that affect mood and the emotional aspect of pain reducing response,
• sleep disturbance and a higher-than-average rate of a sleep disorder called periodic limb movement disorder (PLMD),
• an immune system that causes inflammation, pain, fatigue, and lower tolerance to pain,
• increased rates of cyclic alternating sleep pattern (CAP)

Physiological & Neurochemical Abnormalities
• lower serotonin levels,
• abnormalities in brain scans in pain processing centres,
• abnormalities in pain-related chemical transmitters in the spinal fluid (particularly substance P, nerve growth factor, serotonin, norepinephrine, and corticotropin releasing factor)
• elevated levels of pro-inflammatory cytokines linking between the immune and the neurological systems,
• impaired communication between the base of the brain and peripheral tissues in modulating increased noxious signals,
• muscles related to movement tend to be tight and knotted with myofascial trigger points
• high levels of a nitric oxide-producing enzyme
• excessive levels of oxidative chemicals that irritate the connective tissues in the tiny space between the muscle fibres,
• reduced blood flow to the muscles
• reduced number of capillaries supplying nutrients to the tissues,
• lower levels of Calcium, Magnesium, Iron and Manganese in hair mineral analysis
• overlapping chemical sensitivity problems
• specific trigger points throughout body
• frequently concomitant with Temporal Mandibular Joint Syndrome
• some cases of low Potassium

Prepared by Rory F. Richardson, Ph.D.

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One thought on “What We Know About Fibromyalgia So Far

  1. Fear Dr. Rory my stepmother was diagnosed with fibromyalgia 2 years ago and have been noticing some different things that aren’t listed in the symptoms, also I have a theory that fibromyalgia is a hereditary disease. I would love to hear you thoughts on this theory.

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